Dual-receptor design
Co-activation of GIP and GLP-1 receptor systems in engineered cell lines is the compound's defining analytical characteristic, studied with receptor-specific controls.
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Compound profile
Metabolic research peptidesGLP2 T1RZ
GLP2 T1RZ is a 39-amino-acid dual GIP/GLP-1 receptor agonist peptide with a C20 fatty-diacid side chain — the reference compound of the dual-incretin class for in-vitro studies.
GLP2 T1RZ is a 39-amino-acid peptide engineered to activate both the GIP and GLP-1 receptors — the defining feature of the dual-incretin class. A C20 fatty-diacid side chain mediates albumin binding, the same acylation strategy used across long-acting peptide analogs. The compound is supplied as a lyophilized reference material for dual-receptor binding and signaling assays in engineered cell systems.
Structure and class
In cell-based assays GLP2 T1RZ acts at both incretin receptors; published in-vitro work compares its binding and signaling across the two receptor systems, which is what defines the compound analytically. The acylation chemistry underlies its albumin binding, measurable in cell-free protein-binding assays, and every batch carries an MS-confirmed mass and HPLC purity assessment.
Chemistry and analytical notes
Notes cover structural and analytical chemistry; each link runs a live PubMed search for the topic.
Acylation chemistry
The C20 fatty-diacid side chain mediates albumin binding; acylated peptides require low-binding consumables and careful solution documentation.
Search PubMedAnalytical identity
MS confirms the 39-residue mass and HPLC the purity of every batch; the batch-specific COA links analytical results to the material actually used.
Search PubMedAssay design notes
Receptor-selectivity experiments separate the two receptor systems so results can be attributed to the correct target — a standard control requirement in dual-agonist work.
Search PubMedHandling & storage
Store lyophilized at −20°C, protected from light and moisture. Reconstitute with reconstitution-grade sterile water under aseptic technique; keep the solution at 2–8°C, avoid repeated freeze–thaw cycles and use within your protocol's stability window. For laboratory research use only — not for human or veterinary use.
For laboratory research use only
All products are sold strictly for laboratory research purposes only. Not for human or veterinary consumption, diagnostic, or therapeutic use. The information on this page is a chemistry and handling summary for qualified researchers — it is not medical advice, and nothing here constitutes a claim of safety or efficacy in humans.
GLP2 T1RZ
Source this compound for your laboratory
Every batch is released only at ≥99% HPLC purity with an MS identity check, registered against a batch number you can verify online before you open the vial.