Fragment-analog design
The N-terminal ACTH(4-10) core with a Pro-Gly-Pro extension is the analog's defining structural feature, confirmed by MS on every batch.
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Compound profile
Ancillary & lab suppliesSemax
Synthetic Met-Glu-His-Phe-Pro-Gly-Pro heptapeptide — an ACTH(4-10)-fragment analog stabilized by a Pro-Gly-Pro tail, for structural and analytical studies in vitro.
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic analog of the ACTH(4-10) fragment, stabilized by a C-terminal Pro-Gly-Pro extension and developed within the Russian neuropeptide-chemistry tradition. It is one of the most-cited synthetic neuropeptide analogs in that literature, with published work spanning sequence confirmation, proteolytic stability and receptor-interaction assays in vitro.
Structure and class
Semax retains the ACTH(4-10) core sequence while the Pro-Gly-Pro tail measurably slows proteolytic degradation in enzyme assays — the structural feature that made the analog a standard subject of peptide-stability chemistry. Laboratory use focuses on characterized cell-free and cell-culture systems with documented controls.
Chemistry and analytical notes
Notes cover structural and analytical chemistry; each link runs a live PubMed search for the topic.
Proteolytic resistance
Stability studies quantify the degradation kinetics of the extended analog relative to the unmodified fragment.
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HPLC purity and MS mass confirmation are reported per batch, tying experimental material to its analytical record.
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Semax is studied alongside Selank in comparative work on Pro-Gly-Pro-extended analogs — a recurring pairing in the neuropeptide-chemistry literature.
Search PubMedHandling & storage
Store lyophilized at −20°C, protected from light and moisture. Reconstitute with reconstitution-grade sterile water under aseptic technique; keep the solution at 2–8°C, avoid repeated freeze–thaw cycles and use within your protocol's stability window. For laboratory research use only — not for human or veterinary use.
For laboratory research use only
All products are sold strictly for laboratory research purposes only. Not for human or veterinary consumption, diagnostic, or therapeutic use. The information on this page is a chemistry and handling summary for qualified researchers — it is not medical advice, and nothing here constitutes a claim of safety or efficacy in humans.
Semax
Source this compound for your laboratory
Every batch is released only at ≥99% HPLC purity with an MS identity check, registered against a batch number you can verify online before you open the vial.