Molecular design
The Aib8 substitution and the C18 fatty-diacid side chain at Lys26 are the two design features that produce albumin binding and DPP-IV resistance in this peptide class.
Search PubMedAll compound profiles
Compound profile
Metabolic research peptidesGLP1 S3MA
GLP1 S3MA is a 31-amino-acid GLP-1 receptor agonist peptide engineered for albumin binding and DPP-IV resistance — a reference compound of the incretin class for in-vitro studies.
GLP1 S3MA is a 31-amino-acid analog of human GLP-1 engineered for an extended molecular half-life: an Aib substitution at position 8 blocks DPP-IV cleavage, and a C18 fatty-diacid side chain attached at Lys26 mediates reversible albumin binding. These two structural features are the defining design elements of long-acting incretin-class peptides and the basis of the compound's role as a reference material in receptor-binding and protein-binding studies.
Structure and class
GLP1 S3MA activates GLP-1 receptors — class-B G-protein-coupled receptors studied in engineered cell systems — and its fatty-acid side chain slows clearance through albumin binding, a property measurable directly in cell-free protein-binding assays. The compound is characterized analytically batch by batch: sequence mass confirmed by MS, purity assessed by HPLC.
Chemistry and analytical notes
Notes cover structural and analytical chemistry; each link runs a live PubMed search for the topic.
Albumin-binding chemistry
Reversible fatty-acid-mediated albumin binding is measurable in cell-free binding assays and is a standard characterization endpoint for acylated peptides.
Search PubMedAnalytical identity
Each batch is verified by MS against the theoretical mass and purity-assessed by HPLC; the certificate of analysis ties the analytical record to the batch number.
Search PubMedHandling in solution
Acylated peptides are surface-active: low-binding consumables and documented solvent, concentration and preparation time improve reproducibility.
Search PubMedHandling & storage
Store lyophilized at −20°C, protected from light and moisture. Reconstitute with reconstitution-grade sterile water under aseptic technique; keep the solution at 2–8°C, avoid repeated freeze–thaw cycles and use within your protocol's stability window. For laboratory research use only — not for human or veterinary use.
For laboratory research use only
All products are sold strictly for laboratory research purposes only. Not for human or veterinary consumption, diagnostic, or therapeutic use. The information on this page is a chemistry and handling summary for qualified researchers — it is not medical advice, and nothing here constitutes a claim of safety or efficacy in humans.
GLP1 S3MA
Source this compound for your laboratory
Every batch is released only at ≥99% HPLC purity with an MS identity check, registered against a batch number you can verify online before you open the vial.