Scaffold relationship
PT-141 arises from structure–activity modification of the Melanotan II heptapeptide scaffold, retaining the cyclic core while shifting receptor-subtype interactions.
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Compound profile
Ancillary & lab suppliesPT-141
Cyclic heptapeptide melanocortin-receptor ligand with functional selectivity for MC4R and MC3R — a tool compound for receptor-subtype assays in vitro.
PT-141 is a cyclic heptapeptide derived from the Melanotan II scaffold through structure–activity work that shifted its receptor-interaction profile toward central melanocortin receptors. It is supplied as a lyophilized research material for melanocortin receptor-binding and signaling assays in engineered cell systems.
Structure and class
In cell-based assays PT-141 acts at melanocortin receptors with functional selectivity for MC4R and MC3R. Its interest in the laboratory is strictly as a subtype-selective ligand: receptor-binding and signaling experiments use it to separate MC4R-mediated from MC1R-mediated readouts under controlled conditions.
Chemistry and analytical notes
Notes cover structural and analytical chemistry; each link runs a live PubMed search for the topic.
Subtype-selective binding
In-vitro binding studies at defined melanocortin subtypes characterize its MC4R/MC3R interaction profile.
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Receptor-selective comparators and documented cell-line context are required so mixed-subtype effects are not attributed to a single receptor.
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Every batch carries an MS-confirmed mass and an HPLC purity assessment against the certificate of analysis.
Search PubMedHandling & storage
Store lyophilized at −20°C, protected from light and moisture. Reconstitute with reconstitution-grade sterile water under aseptic technique; keep the solution at 2–8°C, avoid repeated freeze–thaw cycles and use within your protocol's stability window. For laboratory research use only — not for human or veterinary use.
For laboratory research use only
All products are sold strictly for laboratory research purposes only. Not for human or veterinary consumption, diagnostic, or therapeutic use. The information on this page is a chemistry and handling summary for qualified researchers — it is not medical advice, and nothing here constitutes a claim of safety or efficacy in humans.
PT-141
Source this compound for your laboratory
Every batch is released only at ≥99% HPLC purity with an MS identity check, registered against a batch number you can verify online before you open the vial.