Structural features
The pentapeptide carries an Aib residue and D-amino-acid substitutions that resist proteolytic cleavage — design features typical of engineered receptor ligands.
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Compound profile
Secretagogues & GHRH analogsIpamorelin
Synthetic pentapeptide ligand of the ghrelin receptor (GHS-R1a), used as a reference compound in receptor-binding and selectivity assays in vitro.
Ipamorelin is a synthetic pentapeptide first described by a Novo Nordisk research group in the late 1990s. It is built with non-natural residues — including an aminoisobutyric-acid position and D-amino-acid substitutions — that confer proteolytic stability, and its literature role is that of a selective ghrelin-receptor (GHS-R1a) ligand for comparative in-vitro characterization.
Structure and class
In cell-based assays ipamorelin acts as an agonist at the ghrelin receptor (GHS-R1a). Its published receptor-selectivity profile across related G-protein-coupled receptors is what made it a standard reference ligand in binding and signaling assays; selectivity data are assay- and cell-line-dependent and should be verified in the system under study.
Chemistry and analytical notes
Notes cover structural and analytical chemistry; each link runs a live PubMed search for the topic.
Receptor-binding profile
Published binding studies characterize affinity and selectivity at GHS-R1a in vitro; these assays define the compound's reference role in comparative panels.
Search PubMedComparative assay panels
In-vitro panels compare ipamorelin against related peptide ligands under identical conditions to isolate receptor-mediated from off-target signals.
Search PubMedAnalytical identity
Each batch is confirmed by MS and purity-assessed by HPLC; documented peptide content distinguishes nominal from analytically confirmed concentration.
Search PubMedHandling & storage
Store lyophilized at −20°C, protected from light and moisture. Reconstitute with reconstitution-grade sterile water under aseptic technique; keep the solution at 2–8°C, avoid repeated freeze–thaw cycles and use within your protocol's stability window. For laboratory research use only — not for human or veterinary use.
For laboratory research use only
All products are sold strictly for laboratory research purposes only. Not for human or veterinary consumption, diagnostic, or therapeutic use. The information on this page is a chemistry and handling summary for qualified researchers — it is not medical advice, and nothing here constitutes a claim of safety or efficacy in humans.
Ipamorelin
Source this compound for your laboratory
Every batch is released only at ≥99% HPLC purity with an MS identity check, registered against a batch number you can verify online before you open the vial.